MC3 점액표피양 암종세포에서 비타민 K2의 항암효과
Anticancer Effect of Vitamin K2 in MC3 Mucoepidermoid Carcinoma Cells
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장분실:Jang Boon-sil
오세준:Oh Se-Jun/신지애:Shin Ji-Ae/조남표:Cho Nam-Pyo/조성대:Cho Sung-Dae
KMID : 0829220140380050267
Abstract
Background. Vitamin K (VK) is a fat-soluble vitamin and is known to have anticancer activity in various cancer cell lines. However, there is no report on the anticancer effect of VK2 in mucoepidermoid carcinoma cells. Methods. The effects of VK2 on anti-proliferative and apoptotic activity were recognized by the trypan blue exclusion assay, 4'-6-diamidino-2-phenylindole (DAPI) staining and Western blot analysis. Results. The results showed that VK2 decreased cell viability and induced apoptotic programmed cell death in MC3 cells evidenced by the cleavages of caspase3 and PARP. VK2 treatment clearly increased Bak and truncated Bid (t-Bid) compared with the control treatment whereas it did not alter other Bcl-2 family members. Conclusions. Overall, our results suggest that VK2 can be a good apoptotic inducer accompanied by the increase in Bak and Bid protein. VK2 may be a potent target of anticancer drug candidate for the treatment of oral cancer.
키워드
Vitamin K2; Apoptosis; Bak; Bid; Mucoepidermoid carcinoma cell
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